Jagdish Rai Dudhwal: MFS-T1-C2: Human Genetics

UNIT-I
1. Mendelian Inheritance
any text book
Mendelian inheritance
2. The concept of Genetics polymorphism
concept of polymorphism
DNA profiling
3. Blood groups: ABO, MN and Rh systems, ABH saliva secretion
Forensic Biology by Richard Li: pp.153-173

MNS antigen system
ABO Typing Techniques
4. Haemoglobin
Hemoglobin
Hemoglobin D-Punjab
Confirmatory Tests blood

5. Serum Proteins: Hptoglobin
Serum Protein Polymorphisms
Haptoglobin
6. Inborn errors of metabolism: Albinism, Phenylketonuria and Alkaptonuria PTC

Albinism
Alkaptonuria

Phenylketonuria
Phenylthiocarbamide

PTC: Genes and Bitter Taste
7. taste sensitivity and Glucose
https://en.wikipedia.org/wiki/Sweetness
8. Hardy-Weinberg Law,
The Hardy-Weinberg Law
The Hardy-Weinberg law 2
9. Mutations and Genetic Drift,
http://learn.genetics.utah.edu/content/variation/mutation/
Genetic drift
10. Evolution Molecular basis of Evolution
Molecular Clocks

11. Natural Selection, Mutation,
Evolutionary Genetics
12. Genetic Segregation
Genetic Drift

13. Genetic Distance
IAM based distance measures

Mutation, Migration, and Genetic Drift

14. Effects of Migration, Marriages and Consanguinity,
Mutation
Consanguinity

UNIT-II
1. General introduction Human Cytogenetics, Nomenclature Standardization in Human Cytogenetics
Chromosomes and Cytogenetics
2. Mitosis Meiosis in Males meiosis in Females
and http://www.nature.com/scitable/topicpage/mitosis-and-cell-division-205
and any text book
3. Chromosome structure and cell division
http://www.nature.com/scitable/topicpage/chromosomes-14121320
http://www.nature.com/scitable/topicpage/chromosome-mapping-idiograms-302

4. Human somatic chromosomes, Morphological variability of human chromosomes
http://www.nature.com/scitable/topicpage/karyotyping-for-chromosomal-abnormalities-298

5. Heterochromatin and genetic inactivation: Heterochromatin, the sex chromatin, correlation between the number of chromatin masses and the number of X chromosomes.
http://www.nature.com/scitable/topicpage/x-chromosome-x-inactivation-323

6. Chromosome mutations in Man Numerical and structural changes

and http://www.nature.com/scitable/topicpage/chromosomal-abnormalities-aneuploidies-290

UNIT-III
1. Human Genome Project: Introduction, History, Goals,

https://www.nature.com/scitable/topicpage/dna-sequencing-technologies-key-to-the-human-828/
2. Benefits, Social, Ethical and Legal Issues
Human Genome Project

3. DNA Forensic Databases, Ethical, Legal, and Social Issues Associated with
DNA Databanking, Potential Benefits of DNA Databanking,

Forensics, DNA Fingerprinting, and CODIS

Government plans DNA database to help find missing people
Overview and Concerns Regarding the Indian Draft DNA Profiling Act

Forensic databases: benefits and ethical

and social costs

DNA technology Bill; https://www.youtube.com/watch?v=K3TNB0V73xY

4. Human Genome Diversity Project: Introduction, History, Goals, Benefits
Human Genome Diversity Project

India's human genome diversity project : https://www.youtube.com/watch?v=iKJNPNAKOPs

https://academic.oup.com/nar/article/49/D1/D1225/5937082

5. Genetic Discrimination, Behavioral genetics, Genetics and Violence
Genetics of aggression

Behavioural Genetics: Why Eugenic Selection is Preferable

to Enhancement

THE SCARLET GENE: BEHAVIORAL GENETICS, CRIMINAL LAW, AND RACIAL AND ETHNIC STIGMA

UNIT-IV

1. Eukaryotic genome structure and concepts of genomic analysis
Eukaryotic Genome Complexity
http://www.nature.com/scitable/topicpage/eukaryotic-genome-complexity-437
2. Public sequence databases: DNA, RNA, proteins, whole genomes
http://www.nature.com/scitable/topicpage/genomic-data-resources-challenges-and-promises-743721
UCSC Genome Browser An Introduction tutorial movie
http://www.openhelix.com/showMovie2.cgi?id=27
3. Data mining for homologous sequences
http://www.ncbi.nlm.nih.gov/books/NBK1734/

http://www.ncbi.nlm.nih.gov/books/NBK2590/
How to: Find a homolog for a gene in another organism:
http://www.ncbi.nlm.nih.gov/guide/howto/find-homolog-gene/
BLAST Results- Expect Values, part 1

https://www.youtube.com/watch?v=ZN3RrXAe0uM

BLAST Results: Expect Values, part 2

https://www.youtube.com/watch?v=dzRq-5BrGD4

4. Multiple sequence alignment algorithms
https://en.wikipedia.org/wiki/Multiple_sequence_alignment
6. Phylogenetic trees and molecular evolution
Molecular phylogenetic analysis using ribosomal RNA (rRNA)
https://www.researchgate.net/file.PostFileLoader.html?id=55c2206660614b37738b4585&assetKey=AS%3A273825759989760%401442296556699

Molecular Phylogenetics:
http://www.ncbi.nlm.nih.gov/books/NBK21122/

7. Microarrays and transcriptome analysis
http://projects.nfstc.org/pdi/Subject09/pdi_s09_m03_01_b.htm
How Does a DNA Microarray Work.mp4
https://www.youtube.com/watch?v=pWk_zBpKt_w
8. The proteome, metabolome, glycome, lipidome, and interactome
http://www.nature.com/scitable/topicpage/transcriptome-connecting-the-genome-to-gene-function-605
http://www.nature.com/scitable/topicpage/the-proteome-discovering-the-structure-and-function-613
9. Human genes and genetic disorders
Online Mendelian Inheritance in Man (OMIM): A Directory of Human Genes and Genetic Disorders:
http://citeseerx.ist.psu.edu/viewdoc/download?rep=rep1&type=pdf&doi=10.1.1.220.1899
10. Ethics in human bioinformatics and genomics
Bioethics in Genetics:
http://www.nature.com/scitable/topicpage/bioethics-in-genetics-42093
12 Non-Human, medical, and research applications
Genetic Inequality: Human Genetic Engineering:
http://www.nature.com/scitable/topicpage/genetic-inequality-human-genetic-engineering-768
Genetically Modified Organisms (GMOs): Transgenic Crops and
Recombinant DNA Technology:
http://www.nature.com/scitable/topicpage/genetically-modified-organisms-gmos-transgenic-crops-and-732